Journal article
Reversal of functional loss in a rat model of chronic intraocular pressure elevation
HH Liu, Z He, CTO Nguyen, AJ Vingrys, BV Bui
Ophthalmic and Physiological Optics | WILEY | Published : 2017
DOI: 10.1111/opo.12331
Abstract
Purpose: This pilot study considered whether intraocular pressure (IOP) lowering could reverse ganglion cell dysfunction in a rat model of chronic ocular hypertension. Methods: A circumlimbal suture was applied in one eye to induce ocular hypertension (n = 7) in Long-Evans rats. The contralateral eye served as an untreated control. After 8 weeks of IOP elevation the suture was removed to lower IOP for the remaining 7 weeks. Electroretinogram (ERG) and optical coherence tomography (OCT) were measured at baseline, 2, 4, 8, 12 and 15 weeks. Retinae were collected for histology at week 15. Results: In sutured eyes, IOP was elevated by 7–11 mmHg above control eyes (12 ± 0.2 mmHg [standard error o..
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Awarded by Australian Research Council
Funding Acknowledgements
Dr Jelena Kezic and Dr Xiangting Chen from Monash University assisted with the slide scanning for the histological assessment. This study was supported by National Health and Medical Research Council of Australia Grants (1046203) and an Australian Research Council Fellowship (FT130100388). The funding bodies had no involvement in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.